Dr Clara Sze-Man TANG 鄧詩敏

Dr Clara Sze-Man TANG 鄧詩敏

Dr Clara Sze Man TANG

Research Assistant Professor

  • BSc, MPhil, PhD
phone (852) 2831 5101
email claratang@hku.hk
Expertise
  • Paediatric surgery
  • Genetics
Biography

Dr Clara Sze-Man Tang obtained her PhD in statistical genetics from the University of Hong Kong in 2010 and received her postdoctoral training in asthma genetics and bioinformatics at the QIMR Berghofer Medical Research Institute, previously known as Queensland Institute of Medical Research (QIMR). She joined the Department of Surgery in 2013 and is currently a Research Assistant Professor.

Her research interest is on elucidating the genetic basis of complex diseases, including cardiovascular diseases and congenital disorders, such as Hirschsprung disease (HSCR) and congenital heart diseases. Through genome-wide association and copy number analyses, Dr Tang and colleagues successfully identified novel common and rare genetic variants predisposing to HSCR, blood lipid levels (important risk factors for coronary artery disease) and other congenital disorders. She is currently focusing on identifying family-segregating and/or rare genetic variants with potentially large effects using the next-generation sequencing (NGS) approaches.

Research interests

  • Genetics and genomics of Hirschsprung disease and other birth defects
  • Genetics of cardiovascular diseases and their risk factors

Academic Appointment
Oct 2015 – present Research Assistant Professor
Honorary Assistant Professor

Department of Surgery, The University of Hong Kong, Hong Kong
Oct 2012 – Oct 2015 Postdoctoral Fellow
Department of Psychiatry, The University of Hong Kong, Hong Kong
Sep 2012 – Sep 2013 Visiting Scientist
Asthma Genetics, Queensland Institute of Medical Research, Australia
Sep 2010 – Sep 2012 Research Officer
Genetic Epidemiology, Queensland Institute of Medical Research, Australia
Jan – July 2010 Research Assistant
Department of Surgery, The University of Hong Kong, Hong Kong
Sep – Dec 2006 Research Assistant
Department of Medicine, The University of Hong Kong, Hong Kong

Education
Apr 2010 Ph.D. Statistical genetics
Aug 2006 M.Phil. Bioinformatics
Aug 2004 B.Sc. in Bioinformatics (First Class Honours, Dean’s List)

Honors And Awards
2016 The 66 Annual Meeting of the American Society of Human Genetics, Vanvouver, Canada
  • Reviewers’ Choice Abstract

2012 3rd International Symposium on Development of the Enteric Nervous System. Cells, Signals and Genes, Hong Kong
  • Young Investigator Travel Award

2010 The University of Hong Kong, Hong Kong
  • Outstanding Research Postgraduate Student

2009 14th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, Hong Kong
  • Semifinalist for the Best Presentation Award

  • Best Presentation Award of the session on Public Health, Reproduction & Development and Musculoskeletal System

2008 6th Asia Pacific Bioinformatics Conference, Kyoto, Japan.
  • Best Poster Award

2005 3rd Hong Kong Medical Genetics Conference, Hong Kong.
  • Outstanding Free Paper Award

Publications

Journal article
39 publications, 15 as first author, 1 as corresponding author

  • Google Scholar: Clara S Tang

  • H-index
    18
    Number of citations
    1108

  • Scopus ID: 35764635500

  • H-index
    15
    Number of citations
    768

Journal articles († co-first authors)
(Citation(C) is based on Scopus; Impact factor(IF) is based on JCR Science Edition 2013)

Year Publication
2017

Hsu JSJ, So MT, Tang CS, Karim A, Porsch R, Wong C, Yu M, Yeung F, Xia H, Zhang R, Cherny SS, Chung PHY, Wong KKY, Sham PC, Ngo ND, Li MX, Tam PKH, Lui VCH, Garcia-Barceló MM. The Caudal Type Homeo Box Transcription Factor 2 (CDX2) gene is recurrently mutated with de novo variants in patients with persistent cloaca. Hum Mol Genet (in press).

2017

Tang CS, Dattani S, So MT, Cherny SS, Tam PKH, Sham PC, Garcia-Barceló MM. Actionable secondary findings from whole-genome sequencing of 954 East Asians: ethnic similarities and differences. Hum Genet (in press).

2017

Hemani G, Zheng J, Wade KH, Laurin C, Elsworth B, Burgess S, Bowden J, Langdon R, Tan V, Yarmolinsky J, Shihab HA, Timpson N, Evans DM, Relton C, Martin RM, Smith GD, Gaunt TR, Haycock PC, The MR-Base Collaboration. MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations. Preprint at BioRxiv, http://dx.doi.org/10.1101/078972

2017

Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS, Dorajoo R, Li H, Long J, Guo X, Xu M, Spracklen CN, Chen Y, Liu X, Zhang Y, Khor CC, Liu J, Sun L, Wang L, Gao Y, Hu Y, Yu K, Wang Y, Cheung CYY, Wang F, Huang J, Fan Q, Cai Q, Chen S, Shi J, Yang X, Zhao W, Sheu WH, Cherny SS, He M, Feranil AB, Adair LS, Gordon-Larsen P, Du S, Varma R, Chen YI, Shu XO, Lam KSL, Wong TY, Ganesh SK, Mo Z, Hveem K, Fritsche L, Nielsen JB, Tse HF, Huo Y, Cheng CY, Chen YE, Zheng W, Tai ES, Gao W, Lin X, Huang W, Abecasis G, GLGC Consortium, Kathiresan S, Mohlke KL, Wu T, Sham PC, Gu D, Willer C (2017) Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants contributing to lipid levels and coronary artery disease. Nat Genet 49(12):1722.

2017

The Telomere Length Mendelian Randomisation Collaboration (2017) Association between telomere length and risk of cancer and nonneoplastic diseases. JAMA Onco, 3(5):636-651.

2017

Cheung CYY, Tang CS, Xu A, Lee CH, Au KW, Xu L, Fong CHY, Kwok KHM, Chow WS, Woo YC, Yuen MMA, Cherny SS, Hai JSH, Cheung BMY, Tan KCB, Lam TH, Tse HF, Sham PC, Lam KSL (2017) An exome-chip association analysis in Chinese reveals a functional missense variant of GCKR that regulates FGF21 levels. Diabetes 66(6):1723-1728.

2017

Cheung CYY†, Tang CS†, Xu A, Lee CH, Au KW, Xu L, FongCHY, Kwok KHM, Chow WS, WooYC, Yuen MMA, Hai JSH, Jin YL, Cheung BMY, Tan KCB, Cherny SS, Zhu F, Zhu T, Thomas GN, Cheng KK, Jiang CQ, Lam TH, Tse HF, Sham PC, Lam KSL (2017) Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese. Diabetologia, 60(1):107-115.

2017

Gui H†, Schriemer D†, Cheng WC†, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ESW, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PKH, Garcia-Barceló MM & Hofstra R (2017) De Novo mutations in Hirschsprung patients link Central Nervous System genes to the development of the Enteric Nervous System. Genome Biol, 18:48.

2016

Tang CS, Gui H, Kapoor A, Kim J, Luzón-Toro B, Pelet A, Burzynski G, Lantieri F, So MT, Berrios C, Shin HD, Fernández RM, Le TL, Verheij JBGM, Matera I, Cherny SS, Nandakumar P, Cheong HS, Antiñolo G, Amiel J, Seo JM, Kim DY, Oh JT, Lyonnet S, Borrego S, Ceccherini I, Hofstra RMW, Chakravarti A, Kim HY, Sham PC, Tam PKH & Garcia-Barceló MM (2016) Trans-ethnic meta-analysis of genome-wide association studies for Hirschsprung disease. Hum Mol Genet. 25(23):5265-5275.

2016

Wong JKL, Campell D, Ngo ND, Yeung F, Cheng G, Tang CS, Chung PHY, Tran NS, So MT, Cherny SS, Sham PC, Tam PKH, García-Barceló MM (2016) Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes BMC Med Genomics, 9(1):75.

2016

Dai W†, Zheng H†, Cheung AKL, Tang CS, Ko JMY, Wong BWY, Leong MML, Sham PC, Cheung F, Kwong DL, Ngan RKC, Ng WT, Yau CC, Pan J, Peng X, Tung S, Zhang Z, Ji MF, Chiang AK, Lee AW, Lee VH, Lam K, Au KH, (TBC) QE, Lung ML (2016) Whole-Exome Sequencing Identifies MST1R as a Novel Genetic Susceptibility Gene in Nasopharyngeal Carcinoma. Proc Natl Acad Sci U S A, 113(12):3317-22.

2016

Cheung CL, Sing CW, Tang CS, Cheng VKF, Pirmohamed M, Choi CH, Hung CS, Lau EYF, Lee KF, Mak MWH, Leung JYY, Wong TW, Ho AYY, Chan KW, Hung VHF, Tam V, Chung SS, Sham PC, Cheung BMY, Wong ICK, Tan KCB, Kung AWC (2016) HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis. Clin Pharmacol Ther, 99(5):555-61.

2015

Tang CS†, Zhang H†, Cheung CYY†, Xu M†, Ho JCY, Zhou W, Cherny SS, Zhang Y, Holmen O, Au KW, Yu H, Xu L, Jia J, Porsch RM, Sun L, Xu W, Zheng H, Wong LY, Mu Y, Dou J, Fong CHY, Wang S, Hung X, Dong L, Liao Y, Wang J, Lam LSM, Yang ML, Chen J, Siu CW, Xie G, Woo YC, Wu Y, Tan KCB, Hveem K, Cheung BMY, Zöllner S, Xu A, Chen E, Jiang CQ, Zhang Y, Lam TH, Ganesh S, Huo Y, Sham PC, Lam KSL, Willer CJ, Tse HF, Gao W (2015) Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese. Nat Commun, 6:10206.

2015

Luzón-Toro1 B, Gui HS, Ruiz-Ferrer M, Tang CS, Fernández RM, Sham PC, Torroglosa A, Tam PKH, Espino-Paisán L, Cherny SS, Bleda M, Enguix-Riego MV, Dopazo J, Antiñolo G, García-Barceló MM, Borrego S (2015) Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease. Sci Rep, 5:16473.

2015

Liu W†, Wong JKL†, He Q†, Wong EHM, Tang CS, Zhang R, So MT, Wong KKY, Nicholls J, Cherny SS, Sham PC, Tam PKH, Garcia-Barceló MM, Xia H (2015) Chinese family segregating isolated diffuse oesophageal leiomyomatosis: a new COL4A5/COL4A6 deletion and a case of gonosomal mosaicism. BMC Med Genet, 16(1):49.

2015

Cheng WC, Tang CS, Gui H, So MT, Lui VC, Tam PKH and Garcia-Barceló MM (2015) Depletion of the IKBKAP ortholog in zebrafish leads to Hirschsprung disease-like phenotype. World J Gastroenterol, 21(7): 2040-2046.

2014

Gui H, Bao JY, Tang CS, So MT, Ngo DN, Tran AQ, Bui DH, Pham DH, Nguyen TL, Tong A, Lok S, Sham PC, Tam PKH, Cherny SS and Garcia-Barceló MM (2014) Targeted next-generation sequencing on Hirschsprung disease: a pilot study exploits DNA pooling. Ann Hum Genet, 78(5):381-7.

2014

Ferreira MAR†, Matheson MC†, Tang CS, Granell R, Ang W, Hui J, Kiefer AK, Duffy DL, Baltic S, Danoy P, Bui M, Price L, Sly PD, Eriksson N, Madden PA, Abramson MJ, Holt PG, Heath AC, Hunter M, Musk B, AAGC collaborators, Robertson CF, Souëf PL, Montgomery GW, Henderson J, Tung JY, Dharmage SC, Brown MA, James A, Thompson PJ, Pennell C, Martin NG, Evans DM, Hinds DA, and Hopper JL (2014) Genome-wide association analysis of the phenotype asthma-with-hayfever for 20,000 persons identifies 11 risk loci, including variants near ZBTB10 and CLEC16A. J Allergy Clin Immunol, 133(6):1564-71.

2013

Cheng G, Tang CS, Wong EH, Cheng WW, So MT, Miao X, Zhang R, Cui L, Liu X, Ngan ES, Lui VC, Chung PH, Chan IH, Liu J, Zhong W, Xia H, Yu J, Qiu X, Wu XZ, Wang B, Dong X, Tou J, Huang L, Yi B, Ren H, Chan EK, Ye K, O Reilly PF, Wong KK, Sham PC, Cherny SS, Tam PK and Garcia-Barceló MM (2013) Common genetic variants regulating ADD3 gene expression alter biliary atresia risk. J Hepatol, 59(6):1285-91.

2013

Bønnelykke K, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, Linneberg A, Curtin JA, Warrington NM, Standl M, Kerkhof M, Jonsdottir I, Bukvic BK,Kaakinen M, Sleimann P, Thorleifsson G, Thorsteinsdottir U, Schramm K, Baltic S, Kreiner-Møller E, Simpson A, St Pourcain B, Coin L, Hui J, Walters EH, Tiesler CM, Duffy DL, Jones G, Ring SM, McArdle WL, Price L, Robertson CF, Pekkanen J, Tang CS, Thiering E, Montgomery GW, Hartikainen AL, Dharmage SC,Husemoen LL, Herder C, Kemp JP, Elliot P, James A, Waldenberger M, Abramson MJ, Fairfax BP, Knight JC, Gupta R, Thompson PJ, Holt P, Sly P, Hirschhorn JN, Blekic M, Weidinger S, Hakonarsson H, Stefansson K, Heinrich J, Postma DS, Custovic A, Pennell CE, Jarvelin MR, Koppelman GH, Timpson N, Ferreira MA, Bisgaard H, Henderson AJ; Australian Asthma Genetics Consortium (AAGC); EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium (2013) Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet. 45(8):902-6.

2013

Wong EHM†, Cui L†, Ng CL†, Tang CS, Liu XL, So MT, Yip BH, Cheng G, Zhang R, Tang WK, Yang WL, Lau YL, Baum L, Kwan P, Sun LD, Zuo XB, Ren YQ, Yin XY, Miao XP, Liu J, Lui VH, Ngan ESWW, Yuan ZW, Zhang SW, Xia J, Wang H, Sun XB, Wang R, Chang T, Chan IHY, Chung PHY, Zhang XJ, Wong KKY, Cherny SS, Sham PC, Tam PKH and Garcia-Barceló MM (2013) Genome-wide copy number variation study in anorectal malformations. Hum Mol Genet, 22(3):621-31.

2012

Tang CS and Ferreira MAR (2012) A gene-based test of association using canonical correlation analysis. Bioinformatics, 28(6):845-50.

2012

Tang CS†, Cheng G†, So MT†, Yip BH, Miao XP, Wong EH, Ngan ESW, Lui VC, Song YQ, Chan D, Cheung K, Yuan ZW, Lei L, Chung PH, Liu XL, Wong KK, Marshall CR, Scherer S, Cherny SS, Sham PC, Tam PKH and Garcia-Barceló MM (2012) Genome-wide copy number analysis uncovers a new HSCR gene: NRG3. PLoS Genetics, 8(5):e1002687.

2012

Tang CS†, Ngan ESW†, Tang WK†, So MT†, Cheng Guo, Miao XP, Leon TY, Leung BM, Hui KJ, Lui VC, Chen Y, Chan IH, Chung PH, Lui XL, Wong KK, Sham PC, Cherny SS, Tam PK and Garcia-Barceló MM (2012) Mutations in the NRG1 gene are associated with Hirschsprung’s disease. Human Genetics, 131(1):67-76.

2012

van der Harst P, Zhang W, Mateo Leach IV, Sehmi J, Verweij N, Paul DS, Rendon A, Allayee H, Li X, Radhakrishnan A, Tan ST, Albers CA, Al-Hussani AH, Asselbergs FW, Ciullo M, Cucca F, Dina C, Esko T, Evans DM, Ferreira MA, Franke L, Gibson QD, Gögele M, Hartiala J, Hersch M, Holm H, Kanoni S, Kleber ME, Lagou V, Langenberg C, Lopez LM, Lyytikäinen LP, Murgia F, Nolte IM, Olle M, O'Reilly PF, Pirastu N, Portas L, Prokopenko I, Ried JS, Shin SY, Teumer A, Traglia M, Ulivi S, Westra HJ, Zhao JH, Attwood A, Balkau B, Bandinelli S, Bastardot F, Benyamin B, Bo H, Cookson WO,de Bakker PI, de Boer R, de Geus EJ, Dimitriou M, Döring A, Elling U, Eyjolfsson GI, Ferrucci L, Fischer K, Garner S, Genser B, Girotto G, Gudbjartsson DF, Gunnar E, Haller T, Harris SE, Hartikainen AL, Hottenga JJ, Illig T, Jolley J, Kähönen M, Kema IP, Kemp JP, Liang L, Lloyd-Jones H, Loos RJ, Meacham S, Medland SE, Meisinger C, Memari Y, Miller K, Moffatt MF, Nauck M, Nutile T, Olafsson I, Onundarson PT, Parracciani D, Parsa A, Penninger JM, Penninx BW, Pistis G, Pouta A, Pramstaller PP, Raitakari O, Ring SM, Robino A, Ruggiero D, Ruokonen A, Sala C, Sambrook J, Schmidt CO, Sladek R, Smit JH, Starr JM, Stephens J, Sulem P, Tanaka T, Tang CS, Thorsteinsdottir U, van Gilst WH, van Pelt LJ, van Veldhuisen DJ, Visscher PM, Völker U, Voss K, Willemsen G, Winkelmann BR, Wirnsberger G, Algra A, Boomsma DI, d'Adamo AP, Danesh J, Deary IJ, Elliott P, Froguel P, Gasparini P, Greinacher A, Gustav S, Hazen SL, Jarvelin MR, Khaw KT, Lehtimäki T, Lifelines Cohort Study, Maerz W, Martin NG, Metspalu A, Mitchell BD, Montgomery GW, Moore C, Navis G, Pirastu M, Porcu E, Ramirez-Solis R, Scott J, Shuldiner AR, Smith GD, Snieder H, Sorice R, Spector TD, Stefansson K, Stumvoll M, Tang WW, Toniolo D, Tönjes A, Vollenweider P, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Beckmann J, Dedoussis GV, Deloukas P, Hicks AA, Sanna S, Uda M, Gieger C, Soranzo N, Ouwehand WH and Chambers JC (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492(7429):369-75.

2012

Guo Y, Tomlinson B, Chu T, Fang Y, Gui HS, Tang CS, Yip BH, Cherny SS, Hur YM, Sham PC, Lam T, Thomas N (2012) A Genome-wide Linkage and Association Scan Reveals Novel Loci for Hypertension and Blood Pressure Traits. PLoS ONE, 7(2):e31489

2012

Guo Y, Baum LW, Sham PC, Wong V, Ng PW, Lui CHT, Sin NC, Tsoi TH, Tang CS, Kwan JSH, Yip BH, Thomas GN, Kung AWC, Lau YL, Yang W, Cherny SS, Kwan P (2012) Genome-wide association and replication studies identify variants in CAMSAP1L1 as susceptibility loci for symptomatic epilepsy in Chinese subjects. Hum Mol Genet, 21(5):1184–9.

2012

Tang CS and Ferreira MAR (2012) GENOVA: gene overlap analysis of GWAS results. Stat Appl Genet Mol Biol, 11(3):1–13.

2011

Tang CS†, Tang WK†, So MT†, Miao XP, Leung BM, Yip BH, Leon TY, Ngan ESW, Lui VC, Chen Y, Chan IH, Cheung PH, Liu XL, Wu XZ, Wong KK, Sham PC, Cherny SS, Tam PK and Garcia-Barceló MM (2011) Fine mapping and functional analysis of NRG1 for Hirschsprung’s disease. PLoS ONE, 6(1):e16181.

2011

So MT†, Leon TY†, Cheng G†, Tang CS, Miao XP, Cornes BK, Ngo DN, Long C, Ngan ESW, Lui VC, Wu XZ, Wang B, Wang H, Yuan ZW, Huang LM, Li L, Xiz H, Zhu D, Liu J, Nguyen TL, Chan IH, Chung PH, Liu XL, Zhang R, Wong KK, Sham PC, Cherny SS, Tam PKH, Garcia-Barceló MM (2011) RET mutational spectrum in Hirschsprung disease: evaluation of 601 Chinese patients. PLoS ONE, 6(12):e28986.

2011

Garcia-Barceló MM, Miao XP, Tang CS, So HC, Tang WK, Leon TY, So MT, Chen RYL, Cheung EYH, Li T, Tam PKH, Cherny SS and Sham PC (2011) No NRG1 V266L mutation in schizophrenia in Chinese. Psychiatric Genetics, 21(1):47-9.

2010

Tang CS†, Sribudiani Y†, Miao XP, de Vries AR, Burzynski G, So MT, Leon TY, Yip BH, Osinga J, Hui KJ, Verheij JB, Cherny SS, Tam PKH, Sham PC, Hofstra RMW and Garcia-Barceló MM (2010) Fine mapping of the 9q31 Hirschsprung's disease locus. Human Genetics, 127(6):675-83.

2010

Garcia-Barceló MM†, Yeung MY†, Miao XP†, Tang CS†, Chen G, So MT, Ngan ESW, Lui VC, Chen Y, Liu XL, Hui KJ, Li L, Guo WH, Sun XB, You JF, Chan KW, Wu XZ, Song YQ, Chan D, Cheung K, Chung PH, Wong KK, Sham PC, Cherny SS and Tam PKH (2010) Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. Hum Mol Genet, 19(14):2917-25.

2010

Tang CS and Epstein RJ (2010) Adaptive evolution hotspots at the GC-extremes of the human genome: evidence for two functionally distinct pathways of positive selection. Adv Bioinformatics, vol. 2010, Article ID 856825, 7 pages, 2010.

2010

Cornes BK, Tang CS, Leon TY, Hui KJ, So MT, Cherny SS, Sham PC, Tam PKH and Garcia-Barceló MM (2010) Haplotype analysis reveals a possible founder effect of RET mutation R114H for Hirschsprung's disease in Chinese. PLoS ONE, 5(6):e10918.

2009

Garcia-Barceló MM†, Tang CS†, Ngan ESW, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC and Tam PK (2009) Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. Proc Natl Acad Sci U S A, 106(8): 2694-9.

2008

Garcia-Barceló MM, Fong PY, Tang CS, Miao XP, So MT, Yuan ZW, Li L, Guo WH, Liu L, Wang B, Sun XB, Huang LM, Tou JF, Wong KK, Ngan ESW, Lui VC, Cherny SS, Sham PC and Tam PK (2008) Mapping of a Hirschsprung's disease locus in 3p21. Eur J Hum Genet, 16(7):833-40.

2007

Tang CS and Epstein RJ (2007) A structural split in the human genome. PLoS ONE, 2(7):e603.

2006

Tang CS, Zhao YZ, Smith DK and Epstein RJ (2006) Intron length and accelerated 3' gene evolution. Genomics, 88(6):682-9."


Conference Abstracts
Oral presentations
  1. Hofstra R, Schriemer D, Gui H, Cheng W, Griseri P, Pelet A, Ruiz-Ferrer M, Berrios C, van Ijcken W, van den Hout M, Sribudiani Y, Chaudan R, Tam PKH, Tang CS, Matera I, Antinolo I, Chakravarti A, Borrego S, Lyonnet S, Ceccherini I, Eggen B, Amiel J, Garcia-Barceló MM (2014) Functional analysis of genes carrying de novo mutations in 24 sporadic Hirschsprung cases revealed 7 unexpected genes relevant to ENS development. The 64th Annual Meeting of the American Society of Human Genetics, San Diego, USA.

  2. Gui H, HSCR Consortium, Cherny SS, Sham PC, Tang CS, Tam PKH and Garcia-Barceló MM (2013) Patterns and Rates of Exonic de novo Mutations in Sporadic Hirschsprung Disease Patients. European Conference of Human Genetics, Paris, France.

  3. Tang CS, Garcia-Barceló MM, Cherny SS, Sham PC, Tam PKH and the International Hirschsprung Consortium (2012) Meta-analysis of genome-wide association studies of Hirschsprung disease in European and Asian populations. The 3rd International Symposium on Development of the Enteric Nervous System. Cells, Signals and Genes, Hong Kong.

  4. Tang CS and Ferreira MA (2011) A tool to test for functional enrichment of GWAS hits. The 8th GeneMappers Conference, Hobart, Australia.

  5. Garcia-Barceló MM, Tang CS, Ngan ESW, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CKY, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KKY, Cherny SS, Sham PC and Tam PKH (2009) Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung’s disease. The 2nd International Symposium on Development of the Enteric Nervous System. Cells, Signals and Genes, London, UK.

  6. Tang CS, Garcia-Barceló MM, Cherny SS, Sham PC and Tam PKH (2008) Genetic variants on NRG1 confer susceptibility to Hirschsprung’s disease. The 58th Annual Meeting of the American Society of Human Genetics, Philadelphia, USA.

  7. Tang CS, Zhao YZ and Epstein RJ (2005) Patterns of CpG dinucleotides in non-coding DNA. The 3rd Hong Kong Medical Genetics Conference, Hong Kong.

Poster presentations
  1. Tang CS, Gui HS, So MT, Cherny SS, Sham PC, Garcia-Barceló MM, Tam PKH (2016) Deciphering the genetic basis of Hirschsprung disease by whole genome sequencing. The 66 Annual Meeting of the American Society of Human Genetics, Vanvouver, Canada. (Reviewer’ Choice Abstract: scored in the top 10% of poster abstracts)

  2. Dai W, Tang CS, Zheng H, Cheung AKL, Ko JMY, Wong WY, Sham PC, Lung ML (2016) Whole-exome sequencing identifies genetic susceptibility locus associated with familial nasopharyngeal carcinoma. The 17th International Symposium on EBV and Associated Diseases, University of Zürich, Zurich, Switzerland, 8-12 August 2016.

  3. Tang CS, Gui H, Cherny SS, Sham PC, Tam PKH, Kim JH, the International Hirschsprung Disease Consortium and Garcia-Barceló MM (2016) Trans-ethnic meta-analysis of Hirschsprung disease. European Human Genetics Conference, Barcelona, Spain.

  4. Tang CS, So MT, Cherny SS, Sham PC, Tam PKH and Garcia-Barceló MM (2015) Rare variants in sporadic Hirschsprung disease patients. The 65th Annual Meeting of American Society of Human Genetics, Baltimore, USA.

  5. Zheng H, Dai W, Tang CS, Cheung AKL, Ko JMY, Sham PC and Lung ML (2015) Unraveling the genetic basis of nasopharyngeal carcinoma using next-generation sequencing approaches. 106th American Association of Cancer Research. Philadelphia, Pennsylvania, USA.

  6. Gui HS, Tang CS, Cherny SS, Sham PC, Tam PKH, Garcia-Barceló MM (2014) Integrative genomic profile for a patient with Hirschsprung disease. The second conference of the International Rare Diseases Research Consortium (IRDiRC). Futian Sheraton Hotel, Shenzhen, China.

  7. Liu W, Wong JK, He Q, Wong EH, Tang CS, Zhang R, So MT, Wong K, Nicholls J, Cherny SS, Sham PC, Tam PKH, Garcia-Barceló MM and Xia H (2014) Chinese family segregating isolated diffuse oesophageal leiomyomatosis: a new COL4A5/COL4A6 deletion and a case of gonosomal mosaicism. The 64th Annual Meeting of the American Society of Human Genetics, San Diego, USA.

  8. Dai W, Zheng H, Tang CS, Sham PC, Ko JMY, Cheung AKL and Lung ML (2014) Using Next-generation Whole-Exome Sequencing Approaches to Elucidate the Genetic Basis for Nasopharyngeal Carcinoma. Gorden Research Conference Genomic Instability, Hong Kong.

  9. Hofstra RMW, Gui H, Schriemer D, Griseri P, Pelet A, Ruiz-Ferrer M, Berrios C, van Ijcken W., van den Hout M, Tam PKH, Cheng W, Tang CS, Eggen BJL, Matera I, Ceccherini I, Amiel J, Lyonnet S, Antinolo G, Borrego S, Chakravarti A and Garcia-Barceló MM (2014) Exonic de novo mutations in sporadic Hirschsprung disease. European Conference of Human Genetics, Milan, Italy.

  10. Tang CS, Wong EH., Gui H, Cherny SS, Sham PC, Tam PKH and Garcia-Barceló MM (2013) Comprehensive comparison of copy number variations detection using Illumina Omni 2.5M and Affymetrix CytoScan arrays. The 63nd Annual Meeting of the American Society of Human Genetics, Boston, USA.

  11. The 62nd Annual Meeting of the American Society of Human Genetics, San Francisco, USA.

    1. Tang CS, Hinds D and Ferreira MAR (2012) Association analysis between X-chromosome variants and asthma in 50,000 individuals.

    2. Ferreira MAR, Tang CS and Chenevix-Trench G (2012) Whole-genome deep-coverage sequencing of asthma genomes.

    3. Garcia-Barceló MM, Cheng G, Tang CS, Liu XL, Zhang RZ, So MT, Wong EHM, Chung PHY, Chan IHY, Liu J, Zhong W, Xia H, Yu J, Wong KKY, Cherny SS, Sham PC, Tam PKH (2012) Fine mapping on chromosome 10q24.2 implicates ADD3 in biliary atresia.

    4. Cherny SS, Wong EHM, Cui L, Ng CL, Tang CS, So MT, Yip BHK, Cheng G, Liu VCH, Sham PC, Tam PKH, Garcia-Barceló MM (2012) Genome-wide copy number variation in anorectal malformations.

  12. The 12th International Congress of Human Genetics, Montréal QC, Canada.

    1. Tang CS and Ferreira MAR (2011) A tool to test for functional enrichment of GWAS hits

    2. Garcia-Barceló MM, Tang CS, So MT, Marshall CR, Scherer S, Cherny SS, Sham PC and Tam PKH (2011) Genome-wide copy number analysis uncovers a new HSCR gene: NRG3.

  13. The 60th Annual Meeting of the American Society of Human Genetics, Washington DC, USA.

    1. Tang CS and Ferreira MAR (2010) A gene-based test of association.

    2. Garcia-Barceló MM, Tang CS, Tang WK, So MT, Sham PC, Cherny SS and Tam PKH (2010) Fine mapping of the NRG1 Hirschsprung’s-associated gene.

    3. Wong WHM, Tang CS, Garcia-Barceló MM, Zhang XJ, Liu JJ, Cherny SS, Sham PC and Tam PKH (2010) Genome-wide association study on Anorectal Malformations in the Chinese Population.

  14. The 59th Annual Meeting of the American Society of Human Genetics, Honolulu, USA.

    1. Tang CS, Garcia-Barceló MM, Cherny SS, Sham PC and Tam PKH (2009) Genome-wide profile of copy number variants for Hirschsprung’s disease.

    2. Cherny SS, Tang CS, Sribudiani Y, Miao XP, So MT, Sham PC, Tam PKH, Garcia-Barceló MM and Hofstra RMW (2009) Fine mapping of Hirschsprung’s disease loci in 9q31.

    3. Yip BH, Tang CS, Cherny SS, Tam PKH, Ngan ESW, Garcia-Barceló MM and Sham PC (2009) Quantifying epistasis between two sets of signaling pathway genes by canonical correlation analysis.

    4. Cornes BK, Tang CS, Leon TY, So MT, Sham PC, Tam PKH and Garcia-Barceló MM (2009) A RET founder mutation in Chinese Hirschsprung’s patients.

    5. Garcia-Barceló MM, Tang WK, Miao XP, Tang CS, So MT, Leon TY, Sham PC, Cherny SS and Tam PKH. (2009) Identification of rare variants in the NRG1 gene of Hirschsprung’s patients.

  15. Tam PKH, Tang CS, Ngan ESW, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CKY, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KMC, Wong KKY, Cherny SS, Sham PC and Garcia-Barceló MM (2009) Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. Neurogastroenterology and Motility, 21(2), XXVII.

  16. Garcia-Barceló MM, Tang CS, Sham PC, Cherny SS, Tam PKH (2008) Genome-wide association study identifies susceptibility loci for biliary atresia. The 58th Annual Meeting of the American Society of Human Genetics, Philadelphia, USA.

  17. Cherny SS, Garcia-Barceló MM, Tang CS, Sham PC and Tam PKH (2008) Genome-wide association study of Hirschsprung's disease. Behavior Genetics, 38(6):618.

  18. Tang CS and Epstein RJ (2008) Divergent roles of intron size and intron number in genetic evolution. The 6th Asian Pacific Bioinformatics Conference, Kyoto, Japan.

  19. Garcia-Barceló MM, Tang CS, Cherny SS, Sham PC and Tam PKH (2007) Genome-wide association study identifies new HSCR loci. The 57th Annual Meeting of the American Society of Human Genetics, San Diego, USA.

  20. Tam PKH, Garcia-Barceló MM, Tang CS, Cherny SS, Sham PC (2007) Genome-wide association study of HSCR disease. The 9th International Meeting on Human Genome Variation and Complex Genome Analysis, Sitges, Spain.

  21. Tang CS, Zhao YZ and Epstein RJ (2007) Characterization of two evolutionary and functional distinct subpopulations of genes with promoter CpG island. The 5th Asia Pacific Bioinformatics Conference, Hong Kong.

  22. Tang CS, Zhao YZ and Epstein RJ (2006) Correlation of intron length with 5'-to-3' decline of transcription-coupled DNA repair and rise of methylation-dependent mutation. The 11th Human Genome Meeting, Helsinki, Finland.


Invited Lectures
  • Tang CS, Gui HS, Tam PKH, Garcia-Barceló MM and the International Hirschsprung Disease Consortium (2015) Rare and common variants in sporadic Hirschsprung disease patients. The 4th International Symposium on Development of the Enteric Nervous System. Cells, Signals and Genes, Rotterdam, the Netherlands.

  • Lecture at Hospital Authority commission training workshop, Clinical Genetics – from bed side to bench side and back to bed side, “Complex disease with SNPs as risk contributors” (2015).


Workshop
  • Junior faculty member of International Workshop on Statistical Methodology for Human Genomic Studies (2011, 2013 and 2015) Boulder, Colorado, USA.

  • Speaker for Genetic Testing: from Virus to Human (2015) Chinese Academy of Medical Science, Beijing, China.

  • Speaker for Next Generation Sequencing (NGS) Data Analysis for Genetic Studies of Human Diseases (2015) The University of Hong Kong.

  • Speaker for Next Generation Sequencing (NGS) Workshop. Application of NGS in Functional Genomics: Theory and Practice (2014) The University of Hong Kong.

  • Speaker for Next Generation Sequencing (NGS) Data Analysis for Genetic Studies of Rare Diseases (2014) The University of Hong Kong.


Teaching
  • Teacher for undergraduate BBMS3009: Genome Science (2016-2018) The University of Hong Kong.

  • Tutor for undergraduate common core course CCGL9042: Evolution of Civilization (2013-2014) The University of Hong Kong.

  • Tutor for undergraduate common core course CCST9025: Genetics and Human Nature (2012-2013) The University of Hong Kong.


Grant
Project Title PC/PI/
Co-PI/
Co-I
Ref. No. Funding Source Amount (HK$) RGC/UGC Funding Start Date Completion Date
Externally peered-reviewed
Identification and functional characterization of Hirschsprung disease susceptibility genes on chromosome 21 PI 04151966 332,537 NO 1/4/2017 31/3/2019
The International Hirschsprung Disease Consortium: follow-up on whole-exome sequencing data Co-I 02131866 HMRF
567,920
NO 1/6/2015 31/5/2017
Genetics and Functional Genomics of Neural Crest Stem Cells and Associated Disease: Hirschsprung Disease Co-I T12C-
714/14-R
TRS
62,360,000
YES 1/1/2015 31/12/2020
A trans-ethnic meta-analysis of genome-wide association studies for Hirschsprung disease PI 01121796 HMRF
78,800
No 1/1/2014 31/12/2015
Mutational spectrum for dilated cardiomyopathy in Hong Kong Co-I 01121616 HMRF
917,270
No 1/4/2014 31/3/2016
Internally peered-reviewed
Deciphering the co-morbidity between Hirschsprung disease and Down syndrome PI 201606159005 HKU Seeding Fund Programme for Basic Research
150,000
No 30/6/2016 29/6/2018
Copy number variation in syndromic Hirschsprung disease patients PI 201309176158 HKU Small
Project Funding
57,600
No 1/6/2014 30/11/2015

Press Conference
  • Presentation to the press: “HKU leads the first Chinese exome-wide genetic study on blood lipids and coronary artery disease” organized by the LKS Faculty of Medicine, the University of Hong Kong (Dec 2015)
  • Presentation to the press: “HKU scientists discover that DNA changes in the Neuregulin-1 (NRG1) gene increase the risk of Hirschsprung’s Disease” organized by the LKS Faculty of Medicine, the University of Hong Kong (March 2009)

Administration
  • Organizer/person-in-charge of Next Generation Sequencing (NGS) Workshop. Application of NGS in Functional Genomics: Theory and Practice (2014) The University of Hong Kong.
  • Organizer of Genomic Strategic Research Theme Seminars

Referred For Journals
  • Behavior Genetics
  • BMC Genetics
  • Biomedical Signal Processing and Control
  • Gastroenterology
  • Journal of Diabetes Investigation
  • Journal of Human Genetics
  • Orphanet Journal of Rare Diseases
  • PLoS Genetics
  • PLoS ONE
  • Scientific Reports