Dr Lui NG 吳磊

Dr Lui NG 吳磊

Dr Lui NG

Research Assistant Professor

  • BSc, MPhil, PhD
phone (852) 3917 9817
email luing@hku.hk
Research interests

  • Investigations of molecular signaling pathways involved in colorectal cancer development, progression, metastasis and chemoresistance
  • Identification of molecular biomarkers for cancer diagnosis and prognosis
  • Preclinical studies for novel therapeutic drugs using in vitro and in vivo models
  • Characterization and molecular profiling of cancer stem cells in colorectal cancer

Ongoing projects
  • The role of miRNAs and piRNAs in the metastatic progression and chemoresistance of colorectal cancer
  • Dissection of molecular pathways involved in metastatic cancer stem cells in colorectal cancer
  • Identification of non-invasive molecular biomarkers for cancer diagnosis, prognosis and treatment response
  • Preclinical studies on combination therapies in colorectal cancer
Selected publications
  1. Ng L, Wan TM, Man JH, Chow AK, Iyer D, Chen G, Yau TC, Lo OS, Foo DC, Poon JT, Leung WK, Pang RW, Law WL. Identification of serum miR-139-3p as a non-invasive biomarker for colorectal cancer. Oncotarget. 2017 Apr 18;8(16):27393-27400.

  2. Lam CS, Ng L [Co-corresponding author], Chow AK, Wan TM, Yau S, Cheng NS, Wong SK, Man JH, Lo OS, Foo DC, Poon JT, Pang RW, Law WL. Identification of microRNA 885-5p as a novel regulator of tumor metastasis by targeting CPEB2 in colorectal cancer. Oncotarget. 2017 Apr 18;8(16):26858-26870. doi: 10.18632/oncotarget.15844.

  3. Ng L, Wan TM, Lam CS, Chow AK, Wong SK, Man JH, Li HS, Cheng NS, Pak RC, Cheung AH, Yau TC, Lo OS, Foo DC, Poon JT, Poon RT, Pang RW, Law WL. Post-operative Plasma Osteopontin Predicts Distant Metastasis in Human Colorectal Cancer, PLoS One. 2015 May 11;10(5):e0126219. doi: 10.1371

  4. Ng L, Wan T, Chow A, Iyer D, Man J, Chen G, Yau TC, Lo O, Foo CC, Poon JT, Poon RT, Pang R, Law WL. Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer, Stem Cells Int. 2015;2015:247892. doi: 10.1155/2015/247892. Epub 2015 May 27.

  5. Ng L., Poon R.T.P., Yau W.L., Chow K.M., Lam S.C., Li H.S., Yau T.C.C., Law W.L. and Pang R.W.C., Suppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion, Hepatology. 2013, 58(2): 667-79.
    -highlighted by Isobel Leake of Nature Reviews Gastroenterology and Hepatology 10, 260 (May 2013).

  6. Ng L., Poon R.T.P. and Pang R.W.C., Biomarkers for predicting future metastasis of human gastrointestinal tumors (Review), Cellular and Molecular Life Sciences. 2013, Epub on 2013-01-31.

  7. Sun Y., Ng L., [Co-first author] Lam W., Lo C. K., Chan P. T., Yuen Y. L., Wong P. F., Tsang D. S., Cheung W. T., Lee S. S. Identification and characterization of a novel mouse peroxisome proliferator-activated receptor alpha-regulated and starvation-induced gene, Ppsig. Int J Biochem Cell Biol. 2008;40(9):1775-91.

  8. Chow A. K., Ng L., Lam C. S., Wong S. K., Wan T. M., Cheng N. S., Yau T. C., Poon R. T., Pang R. W. The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance. PLoS One. 2013 Nov 11;8(11):e78675.

  9. Chow A.K., Ng L., Li H.S., Cheng C.W., Lam S.C., Yau T.C.C., Cheng P.N.M., Fan S.T., Poon R.T.P. and Pang R.W.C., Anti-tumor efficacy of a recombinant human arginase in human hepatocellular carcinoma, Current Cancer Drug Targets. 2012, 12(9): 1233-1243.

  10. Wan TM, Lam CS, Ng L, Chow AK, Wong SK, Li HS, Man JH, Lo OS, Foo D, Cheung A, Yau T, Poon JT, Poon RT, Law WL, Pang RW. The clinicopathological significance of miR-133a in colorectal cancer, Dis Markers. 2014;2014:919283.

  11. Yau W.L., Lam S.C., Ng L., Chow A.K., Chan T.C., Chan J.Y.K., Wo Y.H., Ng K.T.P., Man K., Poon R.T.P. and Pang R.W.C., Over-expression of miR-106b promotes cell migration and metastasis in hepatocellular carcinoma by activating epithelial-mesenchymal transition process, PLoS One. 2013, 8(3): e57882.

  12. Or YY, Chow AK, Ng L, Fan ST, Yau TC, Poon RT, Pang RW. Survivin depletion inhibits tumor growth and enhances chemosensitivity in hepatocellular carcinoma. Mol Med Rep. 2014 Jul 22

  13. Cheung AH, Iyer DN, Lam CS, Ng L, Wong SKM, Lee HS, Wan T, Man J, Chow AKM, Poon RT, Pang R, Law WL. Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis. Int J Mol Sci. 2017 May 23;18(6). pii: E1106. doi: 10.3390/ijms18061106.

  14. Pun JC, Chan JY, Chun BK, Ng KW, Tsui SY, Wan TM, Lo O, Poon JT, Ng L, Pang R. Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients. Mol Clin Oncol. 2014 Sep;2(5):817-820.

  15. Lam C. S., Cheung A. H., Wong S. K., Wan T. M., Ng L., Chow A. K., Cheng N. S., Pak R. C., Li H. S., Man J. H., Yau T. C., Lo O. S., Poon J. T., Pang R. W., Law W. L. Prognostic significance of CD26 in patients with colorectal cancer. PLoS One. 2014 May 28;9(5):e98582.

  16. Zhang W., Wang J., Zou B., Sardet C., Li J., Lam C. S., Ng L., Pang R., Hung I. F., Tan V. P., Jiang B., Wong B. C. Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1. European Journal of Cancer. 2011, 47(1): 121-130.

  17. Pang R., Law W. L., Chu A. C., Poon J. T., Lam C. S., Chow A. K., Ng L., Cheung L. W., Lan X. R., Lan H. Y., Tan V. P., Yau T. C., Poon R. T., Wong B. C. A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell. 2010, 6(6): 603-15.

  18. Chen W., Zhang X., Chu C., Cheung W.L., Ng L., Lam S. C., Chow A. K., Lau T., Chen M., Li Y., Nie Y., Wong B. C., Pang R., Identification of CD44+ cancer stem cells in human gastric cancer. Hepatogastroenterology. 2013, Epub ahead of print.

Awards and Honors
  • Best research output 2014 in department of Surgery, the University of Hong Kong
  • ESMO Asia Travel grant 2015, European Society for Medical Oncology
Grants
  • Health and Medical Research Fund 2016/2017 (Co-I)
  • Small Project Grant, the University of Hong Kong, 2014 (PI)
  • Small Project Grant, the University of Hong Kong, 2012 (PI)