Expertise

• Bioinformatics, machine learning, single cell transcriptomics

Biography

Dr. Paul David Blakeley graduated from the University of Liverpool, U.K. with a Batchelor of Science degree in Biochemistry. He obtained his Ph.D. in Bioinformatics from the University of Manchester, U.K., and went on to receive postdoctoral training at the Wellcome Trust Sanger Institute and later the Francis Crick Institute, where he worked in several research areas including computational biology, developmental cell biology, human embryonic stem cells, and mitochondrial disease.

His current work focuses on computational analysis and interpretation of single cell transcriptomics data from paediatric disease patients and disease models. He is interested in using bioinformatics approaches to investigate the aetiology of rare congenital diseases such as biliary atresia (BA) and congenital pulmonary airway malformations (CPAM) by uncovering disease-specific alterations of transcriptional regulatory networks which lead to dysregulation of cell differentiation, signalling pathways, and the immune response. Together with colleagues, his work aims to leverage single cell and multiomics analysis to assess the efficacy of disease therapies and investigate the genetic or cellular mechanisms underlying the drug response, leading to improved treatments for paediatric diseases.

Research interests

• Paediatric surgery, single-cell genomics, developmental biology

Publications and achievements

HKU Scholars Hub